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SLC7A2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P52569 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72kDa |
| Dilution | IHC-P (15 µg/ml) |
| Gene ID | 6542 |
|---|---|
| Other Names | Cationic amino acid transporter 2, CAT-2, CAT2, Low affinity cationic amino acid transporter 2, Solute carrier family 7 member 2, SLC7A2, ATRC2, CAT2 |
| Target/Specificity | Human SLC7A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | SLC7A2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC7A2 (HGNC:11060) |
|---|---|
| Function | Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L- homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed:9174363, PubMed:28684763). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
References
Hoshide R.,et al.Genomics 38:174-178(1996).
Closs E.I.,et al.Biochemistry 36:6462-6468(1997).
Nusbaum C.,et al.Nature 439:331-335(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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