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MARK1 / MARK Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - MARK1 / MARK Antibody (Internal) ALS11114
    Anti-MARK1 antibody ALS11114 IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q9P0L2
Reactivity Human, Rabbit, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 89kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 4139
Other Names Serine/threonine-protein kinase MARK1, 2.7.11.1, 2.7.11.26, MAP/microtubule affinity-regulating kinase 1, PAR1 homolog c, Par-1c, Par1c, MARK1 (HGNC:6896)
Target/Specificity Human MARK1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsMARK1 / MARK Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARK1 (HGNC:6896)
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Cellular Location Cell membrane; Peripheral membrane protein Cytoplasm, cytoskeleton. Note=Appears to localize to an intracellular network.
Tissue Location Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.
Research Areas
Citations (0)

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Background

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).

References

Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Zhou H.J.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 395.00
Cat# ALS11114
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