|Dilution||IHC-P (5 µg/ml)|
|Other Names||Protein Wnt-9a, Protein Wnt-14, WNT9A, WNT14|
|Target/Specificity||Human WNT9A. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SCUBE2 (53%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||WNT14 / WNT9A Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Saitoh T.,et al.Biochem. Biophys. Res. Commun. 284:1168-1175(2001).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bergstein I.,et al.Genomics 46:450-458(1997).
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