|Reactivity||Human, Mouse, Rabbit, Monkey, Pig, Horse, Dog|
|Dilution||IHC-P (10-15 µg/ml)|
|Other Names||Protein Wnt-10b, Protein Wnt-12, WNT10B, WNT12|
|Target/Specificity||Human WNT10B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||WNT10B Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain|
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Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Hardiman G.,et al.Cytogenet. Cell Genet. 77:278-282(1997).
Saitoh T.,et al.Int. J. Oncol. 19:1187-1192(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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