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OSTC Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9NRP0 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 58505 |
|---|---|
| Other Names | Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC |
| Target/Specificity | Human OSTC. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | OSTC Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSTC (HGNC:24448) |
|---|---|
| Function | Subunit of STT3A-containing oligosaccharyl transferase (OST- A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:28860277, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:28860277, PubMed:31831667, PubMed:39509507). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116). |
| Cellular Location | Endoplasmic reticulum. Membrane; Multi-pass membrane protein |
Research Areas
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