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OSTC Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9NRP0 |
| Reactivity | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 17kDa |
| Dilution | IHC-P (10 µg/ml) |
| Gene ID | 58505 |
|---|---|
| Other Names | Oligosaccharyltransferase complex subunit OSTC, Hydrophobic protein HSF-28, OSTC |
| Target/Specificity | Human OSTC. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | OSTC Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSTC (HGNC:24448) |
|---|---|
| Function | Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. |
| Cellular Location | Endoplasmic reticulum. Membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
Favier A.-L.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Zhao Z.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ye M.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Peng Y.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
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