|Reactivity||Human, Mouse, Monkey, Pig, Chicken, Horse, Bovine, Guinea Pig, Dog|
|Dilution||IHC-P (2.5-5 µg/ml)|
|Other Names||Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, 22.214.171.124, D-fructose-6-phosphate amidotransferase 1, Glutamine:fructose-6-phosphate amidotransferase 1, GFAT 1, GFAT1, Hexosephosphate aminotransferase 1, GFPT1, GFAT, GFPT|
|Target/Specificity||Human GFPT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GFPT1 / GFAT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.|
|Tissue Location||Isoform 1 is predominantly expressed in skeletal muscle. Not expressed in brain. Seems to be selectively expressed in striated muscle.|
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Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
McKnight G.L.,et al.J. Biol. Chem. 267:25208-25212(1992).
Hillier L.W.,et al.Nature 434:724-731(2005).
DeHaven J.E.,et al.Diabetes 50:2419-2424(2001).
Olsen J.V.,et al.Cell 127:635-648(2006).
Beausoleil S.A.,et al.Nat. Biotechnol. 24:1285-1292(2006).
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