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LRP6 Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - LRP6 Antibody (Internal) ALS11205
    Anti-LRP6 antibody IHC of human hepatocytes and bile duct.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession O75581
Reactivity Human, Rat, Rabbit, Hamster, Monkey, Pig, Horse, Dog
Host Goat
Clonality Polyclonal
Calculated MW 180kDa
Dilution ELISA (1:64000), IHC-P (5 µg/ml),
Additional Information
Gene ID 4040
Other Names Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6
Target/Specificity Human LRP6. This antibody is expected to recognise an epitope corresponding to aa 1546-1560 of human LRP6 protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsLRP6 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRP6
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Note=On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity).
Tissue Location Widely coexpressed with LRP5 during embryogenesis and in adult tissues
Research Areas
Citations (0)

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Background

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

References

Brown S.D.,et al.Biochem. Biophys. Res. Commun. 248:879-888(1998).
Scherer S.E.,et al.Nature 440:346-351(2006).
Semenov M.V.,et al.Curr. Biol. 11:951-961(2001).
Mao B.,et al.Nature 411:321-325(2001).
Caricasole A.,et al.J. Biol. Chem. 278:37024-37031(2003).

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$ 395.00
Cat# ALS11205
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