|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:3000-1:10000), IHC-P (2-5 µg/ml), WB (1:500-1:2000)|
|Other Names||Nuclear respiratory factor 1, NRF-1, Alpha palindromic-binding protein, Alpha-pal, NRF1|
|Target/Specificity||Purified recombinant mouse NRF1 protein corresponding to aa 1-534 of the native protein.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.|
|Precautions||NRF1 / NRF-1 Antibody (aa1-534) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.|
|Tissue Location||Ubiquitously expressed with strongest expression in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
Virbasius C.A.,et al.Genes Dev. 7:2431-2445(1993).
Efiok B.J.S.,et al.J. Biol. Chem. 269:18921-18930(1994).
Gopalakrishnan L.,et al.J. Biol. Chem. 270:18019-18025(1995).
Yang S.J.,et al.Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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