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PPARA / PPAR Alpha Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - PPARA / PPAR Alpha Antibody (N-Terminus) ALS11226
    Anti-PPAR Alpha antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q07869
Reactivity Human, Mouse, Rat, Hamster, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 52kDa
Dilution ELISA (1:8000-1:32000), IHC-P (20 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 5465
Other Names Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR
Target/Specificity PPAR alpha
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPPARA / PPAR Alpha Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPARA
Synonyms NR1C1, PPAR
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Cellular Location Nucleus.
Tissue Location Skeletal muscle, liver, heart and kidney.
Volume 50 µl
Research Areas
Citations (0)

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Background

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.

References

Sher T.,et al.Biochemistry 32:5598-5604(1993).
Mukherjee R.,et al.J. Steroid Biochem. Mol. Biol. 51:157-166(1994).
Tugwood J.D.,et al.Ann. N. Y. Acad. Sci. 804:252-265(1996).
Kobayashi T.,et al.FEBS Lett. 582:2737-2744(2008).
Cho M.-C.,et al.Immunopharmacol. Immunotoxicol. 31:459-467(2009).

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$ 395.00
Cat# ALS11226
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