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HMGN1 Antibody (phospho-Ser20/Ser24)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P05114 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11kDa |
| Dilution | ELISA (1:5000-1:25000), IHC-P (20 µg/ml), WB (1:500-1:2000) |
| Gene ID | 3150 |
|---|---|
| Other Names | Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1, HMGN1, HMG14 |
| Target/Specificity | Amino acids 19-28 of human HMGN protein containing pSer20 and pSer24 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | HMGN1 Antibody (phospho-Ser20/Ser24) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGN1 |
|---|---|
| Synonyms | HMG14 |
| Function | Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). |
| Cellular Location | Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
References
Landsman D.,et al.J. Biol. Chem. 261:16082-16086(1986).
Landsman D.,et al.J. Biol. Chem. 264:3421-3427(1989).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Hattori M.,et al.Nature 405:311-319(2000).
Louie D.F.,et al.Protein Sci. 9:170-179(2000).
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