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HMGN1 Antibody (phospho-Ser20/Ser24)

Rabbit Polyclonal Antibody

     
  • WB - HMGN1 Antibody (phospho-Ser20/Ser24) ALS11229
    Anti-HMNG Antibody - Western Blot.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P05114
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 11kDa
Dilution ELISA (1:5000-1:25000), IHC-P (20 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 3150
Other Names Non-histone chromosomal protein HMG-14, High mobility group nucleosome-binding domain-containing protein 1, HMGN1, HMG14
Target/Specificity Amino acids 19-28 of human HMGN protein containing pSer20 and pSer24
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsHMGN1 Antibody (phospho-Ser20/Ser24) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HMGN1
Synonyms HMG14
Function Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus
Research Areas
Citations (0)

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Background

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

References

Landsman D.,et al.J. Biol. Chem. 261:16082-16086(1986).
Landsman D.,et al.J. Biol. Chem. 264:3421-3427(1989).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Hattori M.,et al.Nature 405:311-319(2000).
Louie D.F.,et al.Protein Sci. 9:170-179(2000).

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$ 395.00
Cat# ALS11229
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