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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   SFRP1 Antibody (aa43-54)   

SFRP1 Antibody (aa43-54)

Rabbit Polyclonal Antibody

     
  • IHC - SFRP1 Antibody (aa43-54) ALS11230
    Anti-SFRP1 antibody IHC of human heart.
  • WB - SFRP1 Antibody (aa43-54) ALS11230
    Western Blot - SFRP1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q8N474
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution ELISA (1:5000-1:25000), IHC-P (20 µg/ml), WB (1:200-1:2000)
Additional Information
Gene ID 6422
Other Names Secreted frizzled-related protein 1, FRP-1, sFRP-1, Secreted apoptosis-related protein 2, SARP-2, SFRP1, FRP, FRP1, SARP2
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSFRP1 Antibody (aa43-54) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SFRP1
Synonyms FRP, FRP1, SARP2
Function Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Cellular Location Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding
Tissue Location Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes
Volume 50 µl
Research Areas
Citations (0)

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Background

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

References

Finch P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:6770-6775(1997).
Melkonyan H.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641(1997).
Zhou Z.,et al.Int. J. Cancer 78:95-99(1998).
Chong J.M.,et al.J. Biol. Chem. 277:5134-5144(2002).
Bafico A.,et al.J. Biol. Chem. 274:16180-16187(1999).

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$ 395.00
Cat# ALS11230
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