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PMAIP1 / NOXA Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - PMAIP1 / NOXA Antibody (N-Terminus) ALS11276
    Immunofluorescence of Noxa in Human Stomach cells with Noxa antibody at 10 ug/ml.
  • IHC - PMAIP1 / NOXA Antibody (N-Terminus) ALS11276
    Anti-NOXA antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q13794
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 6kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 5366
Other Names Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, Immediate-early-response protein APR, Protein Noxa, PMAIP1, NOXA
Target/Specificity synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsPMAIP1 / NOXA Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PMAIP1
Synonyms NOXA
Function Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Cellular Location Mitochondrion
Tissue Location Highly expressed in adult T-cell leukemia cell line
Research Areas
Citations (0)

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Background

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

References

Hijikata M.,et al.J. Virol. 64:4632-4639(1990).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 437:551-555(2005).
Oda E.,et al.Science 288:1053-1058(2000).
Sun Y.,et al.J. Biol. Chem. 280:15561-15568(2005).

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$ 395.00
Cat# ALS11276
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