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CHD2 Antibody (aa1595-1611)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O14647 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 211kDa |
| Dilution | ELISA (1:1000), IHC-P (20 µg/ml), |
| Gene ID | 1106 |
|---|---|
| Other Names | Chromodomain-helicase-DNA-binding protein 2, CHD-2, 3.6.4.12, ATP-dependent helicase CHD2, CHD2 |
| Target/Specificity | Amino acids 1595 to 1611 of human CHD2 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | CHD2 Antibody (aa1595-1611) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHD2 |
|---|---|
| Function | DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). |
| Cellular Location | Nucleus. Note=Binds to myogenic gene promoters. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).
References
Woodage T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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