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>   home   >   Products   >   Primary Antibodies   >   RAD23A / HHR23A Antibody (aa122-135)   

RAD23A / HHR23A Antibody (aa122-135)

Goat Polyclonal Antibody

     
  • IHC - RAD23A / HHR23A Antibody (aa122-135) ALS11349
    Anti-RAD23A / HHR23A antibody IHC of human prostate.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P54725
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 40kDa
Dilution ELISA (1:4000-1:16000), IHC-P (5 µg/ml), WB (1:500-1:2000)
Additional Information
Gene ID 5886
Other Names UV excision repair protein RAD23 homolog A, HR23A, hHR23A, RAD23A
Target/Specificity aa 122-135 of human HR23A protein.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsRAD23A / HHR23A Antibody (aa122-135) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAD23A
Function Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.
Cellular Location Nucleus.
Citations (0)

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Background

Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in vpr-dependent replication of HIV-1 in non- proliferating cells and primary macrophages. Required for the association of HIV-1 vpr with the host proteasome.

References

Masutani C.,et al.EMBO J. 13:1831-1843(1994).
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Withers-Ward E.S.,et al.J. Virol. 71:9732-9742(1997).

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$ 395.00
Cat# ALS11349
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