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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BAD Antibody (C-Terminus)   

BAD Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - BAD Antibody (C-Terminus) ALS11393
    Immunofluorescence of BAD in Rat Thymus cells with BAD antibody at 10 ug/ml.
  • WB - BAD Antibody (C-Terminus) ALS11393
    Western blot of Bad in T24 cell lysates with Bad antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
  • IHC - BAD Antibody (C-Terminus) ALS11393
    Anti-BAD antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q92934
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 18kDa
Dilution IHC-P (2.5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 572
Other Names Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl2-L-8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD, BBC6, BCL2L8
Target/Specificity peptide corresponding to 15 amino acids near the C-terminus of human Bad
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsBAD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAD
Synonyms BBC6, BCL2L8
Function Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Cellular Location Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}
Tissue Location Expressed in a wide variety of tissues.
Research Areas
Citations (0)

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Background

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

References

Yin D.X.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
Wang H.-G.,et al.Cell 87:629-638(1996).
Takayama S.,et al.Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
Ottilie S.,et al.J. Biol. Chem. 272:30866-30872(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS11393
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