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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD209 / DC-SIGN Antibody (Internal)   

CD209 / DC-SIGN Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - CD209 / DC-SIGN Antibody (Internal) ALS11410
    Anti-CD209 / DC-SIGN antibody IHC of human tonsil.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NNX6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 30835
Other Names CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN, DC-SIGN1, CD209, CD209, CLEC4L
Target/Specificity synthetic peptide corresponding to amino acids near the center of human DC-DIGN
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsCD209 / DC-SIGN Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD209
Synonyms CLEC4L
Function Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
Cellular Location Isoform 1: Cell membrane; Single-pass type II membrane protein Isoform 3: Cell membrane; Single-pass type II membrane protein Isoform 5: Cell membrane; Single-pass type II membrane protein Isoform 7: Secreted. Isoform 9: Secreted. Isoform 11: Secreted.
Tissue Location Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes
Research Areas
Citations (0)

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Background

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri- mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.

References

Curtis B.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8356-8360(1992).
Soilleux E.J.,et al.J. Immunol. 165:2937-2942(2000).
Bashirova A.A.,et al.J. Exp. Med. 193:671-678(2001).
Mummidi S.,et al.J. Biol. Chem. 276:33196-33212(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS11410
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(40 western blots)
Availability: 5 days
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