|Application ||WB, IHC-P, IF|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||Nicastrin, NCSTN, KIAA0253|
|Target/Specificity||17 amino acid peptide from near the carboxy terminus of human Nicastrin|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||NCSTN / Nicastrin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Yu G.,et al.Nature 407:48-54(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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