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NCSTN / Nicastrin Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - NCSTN / Nicastrin Antibody (C-Terminus) ALS11421
    Immunofluorescence of Nicastrin in Human Brain cells with Nicastrin antibody at 20 ug/ml.
  • WB - NCSTN / Nicastrin Antibody (C-Terminus) ALS11421
    Western blot of Nicastrin in mouse brain tissue lysate with Nicastrin antibody at (A) 0.5, (B)...
  • IHC - NCSTN / Nicastrin Antibody (C-Terminus) ALS11421
    Anti-NCSTN / Nicastrin antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q92542
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 23385
Other Names Nicastrin, NCSTN, KIAA0253
Target/Specificity 17 amino acid peptide from near the carboxy terminus of human Nicastrin
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsNCSTN / Nicastrin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCSTN
Synonyms KIAA0253
Function Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Cellular Location Membrane; Single-pass type I membrane protein. Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

References

Yu G.,et al.Nature 407:48-54(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11421
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