|Application ||WB, IHC-P, IF, ICC|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, Clan protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf, NLRC4, CARD12, CLAN, CLAN1, IPAF|
|Target/Specificity||synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IPAF / NLRC4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CARD12, CLAN, CLAN1, IPAF|
|Function||Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytosol. Note=Cytoplasmic filaments|
|Tissue Location||Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain|
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Provided below are standard protocols that you may find useful for product applications.
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
Geddes B.J.,et al.Biochem. Biophys. Res. Commun. 284:77-82(2001).
Damiano J.S.,et al.Genomics 75:77-83(2001).
Poyet J.-L.,et al.J. Biol. Chem. 276:28309-28313(2001).
Gingras M.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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