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IPAF / NLRC4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - IPAF / NLRC4 Antibody (C-Terminus) ALS11424
    Immunocytochemistry of Ipaf in THP-1 cells with Ipaf antibody at 10 ug/ml.
  • IF - IPAF / NLRC4 Antibody (C-Terminus) ALS11424
    Immunofluorescence of Ipaf in THP1 cells with Ipaf antibody at 10 ug/ml.
  • IHC - IPAF / NLRC4 Antibody (C-Terminus) ALS11424
    Anti-NLRC4 antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession Q9NPP4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 116kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 58484
Other Names NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, Clan protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf, NLRC4, CARD12, CLAN, CLAN1, IPAF
Target/Specificity synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIPAF / NLRC4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLRC4
Synonyms CARD12, CLAN, CLAN1, IPAF
Function Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.
Cellular Location Cytoplasm. Cytoplasm, cytosol. Note=Cytoplasmic filaments
Tissue Location Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain
Research Areas
Citations (0)

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Background

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis.

References

Geddes B.J.,et al.Biochem. Biophys. Res. Commun. 284:77-82(2001).
Damiano J.S.,et al.Genomics 75:77-83(2001).
Poyet J.-L.,et al.J. Biol. Chem. 276:28309-28313(2001).
Gingras M.,et al.Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS11424
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