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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DAD1 Antibody (C-Terminus)   

DAD1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • ICC - DAD1 Antibody (C-Terminus) ALS11446
    Immunocytochemistry of DAD1 in HepG2 cells with DAD1 antibody at 10 ug/ml.
  • IF - DAD1 Antibody (C-Terminus) ALS11446
    Immunofluorescence of DAD1 in HepG2 cells with DAD1 antibody at 10 ug/ml.
  • WB - DAD1 Antibody (C-Terminus) ALS11446
    Western blot of DAD1 in HepG2 cell lysate with DAD1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
  • IHC - DAD1 Antibody (C-Terminus) ALS11446
    Anti-DAD1 antibody IHC of human prostate.
  • IHC - DAD1 Antibody (C-Terminus) ALS11446
    Anti-DAD1 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession P61803
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 12kDa
Dilution IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 1603
Other Names Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1, Oligosaccharyl transferase subunit DAD1, 2.4.99.18, Defender against cell death 1, DAD-1, DAD1
Target/Specificity peptide corresponding to 14 amino acids near the C-terminus of human DAD1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsDAD1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAD1
Function Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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Background

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).

References

Nakashima T.,et al.Mol. Cell. Biol. 13:6367-6374(1993).
Wang K.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11446
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