|Application ||WB, IHC-P|
|Dilution||IHC-P (2.5 µg/ml)|
|Other Names||Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, TNFRSF27, XEDAR|
|Target/Specificity||Human EDA2R, antibody does not detect mouse EDA2R|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||EDA2R / XEDAR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.|
|Cellular Location||Membrane; Single-pass type III membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
Yan M.,et al.Science 290:523-527(2000).
Sinha S.K.,et al.J. Biol. Chem. 277:44953-44961(2002).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
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