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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   HTRA2 / OMI Antibody (C-Terminus)   

HTRA2 / OMI Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IF - HTRA2 / OMI Antibody (C-Terminus) ALS11460
    Immunofluorescence of OMI in human colon tissue with OMI antibody at 20 ug/ml.
  • WB - HTRA2 / OMI Antibody (C-Terminus) ALS11460
    Western blot of OMI in human colon cell lysates with OMI antibody at (A) 0.5 and (B) 1 ug/ml.
  • IHC - HTRA2 / OMI Antibody (C-Terminus) ALS11460
    Anti-HTRA2 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession O43464
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 27429
Other Names Serine protease HTRA2, mitochondrial, 3.4.21.108, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HTRA2, OMI, PRSS25
Target/Specificity peptide corresponding to 15 amino acids near the C-terminus of human OMI
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsHTRA2 / OMI Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA2
Synonyms OMI, PRSS25
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Cellular Location Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID
Tissue Location Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid
Research Areas
Citations (0)

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Background

Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

References

Faccio L.,et al.J. Biol. Chem. 275:2581-2588(2000).
Gray C.W.,et al.Eur. J. Biochem. 267:5699-5710(2000).
Faccio L.,et al.Genomics 68:343-347(2000).
Hillier L.W.,et al.Nature 434:724-731(2005).
Suzuki Y.,et al.Mol. Cell 8:613-621(2001).

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$ 395.00
Cat# ALS11460
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