|Application ||WB, IHC-P, IF|
|Dilution||IHC-P (5 µg/ml), WB (0.5-1 µg/ml),|
|Other Names||Interleukin-27 receptor subunit alpha, IL-27 receptor subunit alpha, IL-27R subunit alpha, IL-27R-alpha, IL-27RA, Cytokine receptor WSX-1, Cytokine receptor-like 1, Type I T-cell cytokine receptor, TCCR, ZcytoR1, IL27RA, CRL1, TCCR, WSX1|
|Target/Specificity||Synthetic peptide (gsagplqcygvgplgd) corresponding to amino acids 44 to 59 of human TCCR precursor.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||IL27RA / WSX-1 Antibody (aa44-59) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CRL1, TCCR, WSX1|
|Function||Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.
Sprecher C.A.,et al.Biochem. Biophys. Res. Commun. 246:82-90(1998).
Zhang W.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Chen Q.,et al.Nature 407:916-920(2000).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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