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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IL27RA / WSX-1 Antibody (aa44-59)   

IL27RA / WSX-1 Antibody (aa44-59)

Rabbit Polyclonal Antibody

     
  • IF - IL27RA / WSX-1 Antibody (aa44-59) ALS11464
    Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 ug/ml.
  • WB - IL27RA / WSX-1 Antibody (aa44-59) ALS11464
    Western blot of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 ug /ml.
  • IHC - IL27RA / WSX-1 Antibody (aa44-59) ALS11464
    Anti-IL27RA antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q6UWB1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 69kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 9466
Other Names Interleukin-27 receptor subunit alpha, IL-27 receptor subunit alpha, IL-27R subunit alpha, IL-27R-alpha, IL-27RA, Cytokine receptor WSX-1, Cytokine receptor-like 1, Type I T-cell cytokine receptor, TCCR, ZcytoR1, IL27RA, CRL1, TCCR, WSX1
Target/Specificity Synthetic peptide (gsagplqcygvgplgd) corresponding to amino acids 44 to 59 of human TCCR precursor.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsIL27RA / WSX-1 Antibody (aa44-59) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL27RA
Synonyms CRL1, TCCR, WSX1
Function Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes.
Research Areas
Citations (0)

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Background

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms.

References

Sprecher C.A.,et al.Biochem. Biophys. Res. Commun. 246:82-90(1998).
Zhang W.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Chen Q.,et al.Nature 407:916-920(2000).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).

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$ 395.00
Cat# ALS11464
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