|Application ||WB, IHC-P|
|Dilution||IHC-P (2.5 µg/ml), WB (1 µg/ml),|
|Other Names||Modulator of apoptosis 1, MAP-1, MAP1, Paraneoplastic antigen Ma4, MOAP1, PNMA4|
|Target/Specificity||15 amino acid peptide from near the center of human MAP-1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||MOAP1 / MAP1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.|
|Tissue Location||Widely expressed, with high levels in heart and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.
Tan K.O.,et al.J. Biol. Chem. 276:2802-2807(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Baksh S.,et al.Mol. Cell 18:637-650(2005).
Takaji M.,et al.Cereb. Cortex 19:2865-2879(2009).
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