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TIRAP Antibody

Rabbit Polyclonal Antibody

     
  • IF - TIRAP Antibody ALS11489
    Immunofluorescence of TIRAP in Human Heart cells with TIRAP antibody at 20 ug/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P58753
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24kDa
Dilution IHC-P (5 µg/ml), WB (4 µg/ml),
Additional Information
Gene ID 114609
Other Names Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88 adapter-like protein, MyD88-2, TIRAP, MAL
Target/Specificity peptide corresponding to amino acids near the middle of human TIRAP
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsTIRAP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIRAP
Synonyms MAL
Function Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Cellular Location Cytoplasm. Cell membrane. Membrane. Note=Colocalizes with DAB2IP at the plasma membrane
Tissue Location Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain
Research Areas
Citations (0)

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Background

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

References

Fitzgerald K.A.,et al.Nature 413:78-83(2001).
Horng T.,et al.Nat. Immunol. 2:835-841(2001).
Kirk P.B.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Hardy M.P.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).

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$ 395.00
Cat# ALS11489
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