|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||Toll-like receptor 5, Toll/interleukin-1 receptor-like protein 3, TLR5, TIL3|
|Target/Specificity||peptide corresponding to 16 amino acids near the center of human TLR5|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||TLR5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis|
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Provided below are standard protocols that you may find useful for product applications.
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Chaudhary P.M.,et al.Blood 91:4020-4027(1998).
Seya T.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Nakajima T.,et al.Immunogenetics 60:727-735(2008).
Wlasiuk G.,et al.Mol. Biol. Evol. 26:937-949(2009).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).
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