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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   GDF9 / GDF-9 Antibody (aa45-59)   

GDF9 / GDF-9 Antibody (aa45-59)

Rabbit Polyclonal Antibody

     
  • IHC - GDF9 / GDF-9 Antibody (aa45-59) ALS11576
    Anti-GDF9 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O60383
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 51kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 2661
Other Names Growth/differentiation factor 9, GDF-9, GDF9
Target/Specificity Amino acids 45 to 59 of human GDF9
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGDF9 / GDF-9 Antibody (aa45-59) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF9
Function Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Cellular Location Secreted.
Tissue Location Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level)
Research Areas
Citations (0)

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Background

Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

References

Schmutz J.,et al.Nature 431:268-274(2004).
Aaltonen J.,et al.J. Clin. Endocrinol. Metab. 84:2744-2750(1999).
Yamamoto N.,et al.J. Clin. Endocrinol. Metab. 87:2849-2856(2002).
Yamamoto N.,et al.J. Clin. Endocrinol. Metab. 87:4495-4495(2002).
McMahon H.E.,et al.Endocrinology 149:812-817(2008).

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$ 395.00
Cat# ALS11576
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