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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   LEPR / Leptin Receptor Antibody (aa37-52)   

LEPR / Leptin Receptor Antibody (aa37-52)

Rabbit Polyclonal Antibody

     
  • IHC - LEPR / Leptin Receptor Antibody (aa37-52) ALS11593
    Anti-Leptin Receptor antibody IHC of human adrenal.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession P48357
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 132kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 3953
Other Names Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR
Target/Specificity Amino acids 37 to 52 of human LEPR
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsLEPR / Leptin Receptor Antibody (aa37-52) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LEPR
Synonyms DB, OBR
Function Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter- regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane
Tissue Location Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus, but also in skeletal muscle. Detected in fundic and antral epithelial cells of the gastric mucosa (PubMed:19159218) Isoform B and isoform A are expressed by NK cells (at protein level) (PubMed:12504075).
Research Areas
Citations (0)

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Background

Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).

References

Tartaglia L.A.,et al.Cell 83:1263-1271(1995).
Bennett B.D.,et al.Curr. Biol. 6:1170-1180(1996).
Cioffi J.A.,et al.Nat. Med. 2:585-589(1996).
Thompson D.B.,et al.Hum. Mol. Genet. 6:675-679(1997).
Luoh S.-M.,et al.J. Mol. Endocrinol. 18:77-85(1997).

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$ 395.00
Cat# ALS11593
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