|Application ||IHC-P, E|
|Dilution||ELISA (1:1000), IHC-P (10 µg/ml),|
|Other Names||Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR|
|Target/Specificity||Amino acids 37 to 52 of human LEPR|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||LEPR / Leptin Receptor Antibody (aa37-52) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary Low level in lung and kidney. Isoform B is highly expressed in hypothalamus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).
Tartaglia L.A.,et al.Cell 83:1263-1271(1995).
Bennett B.D.,et al.Curr. Biol. 6:1170-1180(1996).
Cioffi J.A.,et al.Nat. Med. 2:585-589(1996).
Thompson D.B.,et al.Hum. Mol. Genet. 6:675-679(1997).
Luoh S.-M.,et al.J. Mol. Endocrinol. 18:77-85(1997).
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