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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PTPRR Antibody (aa249-265)   

PTPRR Antibody (aa249-265)

Rabbit Polyclonal Antibody

     
  • IHC - PTPRR Antibody (aa249-265) ALS11599
    Anti-PTPRR antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q15256
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 74kDa
Dilution ELISA (1:1000), IHC-P (10 µg/ml),
Additional Information
Gene ID 5801
Other Names Receptor-type tyrosine-protein phosphatase R, R-PTP-R, 3.1.3.48, Ch-1PTPase, NC-PTPCOM1, Protein-tyrosine phosphatase PCPTP1, PTPRR, ECPTP, PTPRQ
Target/Specificity Amino acids 249 to 265 of human PTPRR
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPTPRR Antibody (aa249-265) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTPRR
Synonyms ECPTP, PTPRQ
Function Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).
Cellular Location Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm
Tissue Location Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus
Research Areas
Citations (0)

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Background

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

References

Shiozuka K.,et al.Gene 162:279-284(1995).
Augustine K.A.,et al.Anat. Rec. 258:221-234(2000).
Bektas A.,et al.Diabetes 50:204-208(2001).
Knyazev P.,et al.Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS11599
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