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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRB4 / NCK2 Antibody (aa119-276)   

GRB4 / NCK2 Antibody (aa119-276)

Rabbit Polyclonal Antibody

     
  • IHC - GRB4 / NCK2 Antibody (aa119-276) ALS11649
    Anti-NCK2 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O43639
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 8440
Other Names Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta, NCK2, GRB4
Target/Specificity Amino acids 119 to 276 of human NCK2
Reconstitution & Storage +4°C, avoid freezing
PrecautionsGRB4 / NCK2 Antibody (aa119-276) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCK2
Synonyms GRB4
Function Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.
Cellular Location Cytoplasm. Endoplasmic reticulum
Tissue Location Ubiquitous.
Volume 250 µl
Research Areas
Citations (0)

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Background

Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.

References

Chen M.,et al.J. Biol. Chem. 273:25171-25178(1998).
Tu Y.,et al.Mol. Biol. Cell 9:3367-3382(1998).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Braverman L.E.,et al.J. Biol. Chem. 274:5542-5549(1999).
Turner C.E.,et al.J. Cell Biol. 145:851-863(1999).

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$ 395.00
Cat# ALS11649
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