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GRB4 / NCK2 Antibody (aa119-276)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | O43639 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 43kDa |
| Dilution | IHC-P (5 µg/ml) |
| Gene ID | 8440 |
|---|---|
| Other Names | Cytoplasmic protein NCK2, Growth factor receptor-bound protein 4, NCK adaptor protein 2, Nck-2, SH2/SH3 adaptor protein NCK-beta, NCK2, GRB4 |
| Target/Specificity | Amino acids 119 to 276 of human NCK2 |
| Reconstitution & Storage | +4°C, avoid freezing |
| Precautions | GRB4 / NCK2 Antibody (aa119-276) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCK2 |
|---|---|
| Synonyms | GRB4 |
| Function | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. |
| Cellular Location | Cytoplasm. Endoplasmic reticulum |
| Tissue Location | Ubiquitous. |
| Volume | 250 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.
References
Chen M.,et al.J. Biol. Chem. 273:25171-25178(1998).
Tu Y.,et al.Mol. Biol. Cell 9:3367-3382(1998).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Braverman L.E.,et al.J. Biol. Chem. 274:5542-5549(1999).
Turner C.E.,et al.J. Cell Biol. 145:851-863(1999).
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