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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   MICA Antibody (C-Terminus)   

MICA Antibody (C-Terminus)

Rabbit Polyclonal Antibody

  • IHC - MICA Antibody (C-Terminus) ALS11697
    Anti-MICA antibody IHC of human prostate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q29983
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 43kDa
Dilution IHC-P (5 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 100507436
Other Names MHC class I polypeptide-related sequence A, MIC-A, MICA {ECO:0000312|EMBL:CAI41907.1}
Target/Specificity a 16 amino acid peptide from near the carboxy terminus of human MICA
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsMICA Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MICA {ECO:0000312|EMBL:CAI41907.1}
Function Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Cellular Location Cell membrane; Single- pass type I membrane protein Cytoplasm Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum
Tissue Location Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells
Research Areas
Citations (0)

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Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.


Bahram S.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994).
Bahram S.,et al.Immunogenetics 44:80-81(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Leelayuwat C.,et al.Immunogenetics 40:339-351(1994).
Fodil N.,et al.Immunogenetics 44:351-357(1996).

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$ 395.00
Cat# ALS11697
(40 western blots)
Availability: 5 days
Bulk Size
Seasonal Special on Bulk Order
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