|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (5 µg/ml), WB (1 µg/ml),|
|Other Names||Nephrin, Renal glomerulus-specific cell adhesion receptor, NPHS1, NPHN|
|Target/Specificity||14 amino acid peptide from near the carboxy terminus of human Nephrin.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.|
|Precautions||NPHS1 / Nephrin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane|
|Tissue Location||Specifically expressed in podocytes of kidney glomeruli|
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Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
Kestilae M.,et al.Mol. Cell 1:575-582(1998).
Tikhomirov E.,et al.Hum. Genet. 125:334-334(2009).
Grunkemeyer J.A.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Holthoefer H.,et al.Am. J. Pathol. 155:1681-1687(1999).
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