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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VISA / MAVS Antibody (Internal)   

VISA / MAVS Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - VISA / MAVS Antibody (Internal) ALS11742
    Anti-MAVS antibody IHC of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q7Z434
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 57506
Other Names Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA, MAVS, IPS1, KIAA1271, VISA
Target/Specificity 17 amino acid peptide from near the center of human VISA.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsVISA / MAVS Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAVS
Synonyms IPS1, KIAA1271, VISA
Function Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Cellular Location Mitochondrion outer membrane. Mitochondrion. Peroxisome
Tissue Location Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

References

Seth R.B.,et al.Cell 122:669-682(2005).
Xu L.-G.,et al.Mol. Cell 19:727-740(2005).
Meylan E.,et al.Nature 437:1167-1172(2005).
Kawai T.,et al.Nat. Immunol. 6:981-988(2005).
Lad S.P.,et al.Mol. Immunol. 45:2277-2287(2008).

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$ 395.00
Cat# ALS11742
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