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>   home   >   Products   >   Primary Antibodies   >   RIF1 Antibody (aa2406-2419)   

RIF1 Antibody (aa2406-2419)

Rabbit Polyclonal Antibody

     
  • WB - RIF1 Antibody (aa2406-2419) ALS11755
    Anti-Rif1 Antibody - Western Blot.
  • IHC - RIF1 Antibody (aa2406-2419) ALS11755
    Anti-RIF1 antibody IHC of human kidney.
  • IHC - RIF1 Antibody (aa2406-2419) ALS11755
    Anti-RIF1 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q5UIP0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 274kDa
Dilution ELISA (1:5000-1:40000), IHC-P (5 µg/ml), WB (1:500-1:3000)
Additional Information
Gene ID 55183
Other Names Telomere-associated protein RIF1, Rap1-interacting factor 1 homolog, RIF1
Target/Specificity Rif1
Reconstitution & Storage Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing.
PrecautionsRIF1 Antibody (aa2406-2419) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RIF1
Function Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.
Cellular Location Nucleus. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase
Tissue Location Highly expressed in testis.
Citations (0)

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Background

Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.

References

Silverman J.,et al.Genes Dev. 18:2108-2119(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Xu L.,et al.J. Cell Biol. 167:819-830(2004).
Simonsson T.,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 395.00
Cat# ALS11755
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