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NCS1 / Neuronal Calcium Sensor Antibody

Rabbit Polyclonal Antibody

     
  • IF - NCS1 / Neuronal Calcium Sensor Antibody ALS11756
    Anti-FREQUENIN Antibody - Immunofluorescence Microscopy.
  • IHC - NCS1 / Neuronal Calcium Sensor Antibody ALS11756
    Anti-NCS-1 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P62166
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 22kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 23413
Other Names Neuronal calcium sensor 1, NCS-1, Frequenin homolog, Frequenin-like protein, Frequenin-like ubiquitous protein, NCS1, FLUP, FREQ
Target/Specificity Frequenin (recombinant from Mouse with extensive post-translational modifications).
Reconstitution & Storage Store vial at -20 C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing.
PrecautionsNCS1 / Neuronal Calcium Sensor Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NCS1
Synonyms FLUP, FREQ
Function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).
Cellular Location Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions
Volume 50 µl
Research Areas
Citations (0)

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Background

Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity).

References

Lindemeier J.R.,et al.Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
Bao X.G.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Nef S.,et al.Submitted (JUN-1999) to UniProtKB.
Pongs O.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 395.00
Cat# ALS11756
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