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MCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1)

Mouse Monoclonal Antibody

     
  • IF - MCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1) ALS11798
    Confocal immunofluorescence of HepG2 cells using MCL1 mouse monoclonal antibody (green).
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E, IHC-Fr
Primary Accession Q07820
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 8C6, 8C6D4B1
Calculated MW 37kDa
Dilution ELISA (1:10000), IHC-Fr (1:200-1:1000), IHC-P (1:200-1:1000), WB (1:200-1:1000) ,
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Target/Specificity Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsMCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
Volume 1 ea
Research Areas
Citations (0)

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Background

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

References

Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).

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$ 395.00
Cat# ALS11798
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