|Application ||WB, IHC-P, IF, E, IHC-Fr|
|Clone Names||8C6, 8C6D4B1|
|Dilution||ELISA (1:10000), IHC-Fr (1:200-1:1000), IHC-P (1:200-1:1000), WB (1:200-1:1000) ,|
|Other Names||Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3|
|Target/Specificity||Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||MCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.|
|Cellular Location||Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria|
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Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).
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