|Application ||WB, IHC-P, ICC, IP|
|Reactivity||Human, Mouse, Rabbit, Monkey, Horse, Dog|
|Dilution||IHC-P (5 µg/ml)|
|Other Names||Nitric oxide synthase, brain, 188.8.131.52, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS, NOS1|
|Target/Specificity||Human nNOS amino acids 1422-1433 (ESKKDTDEVFSS)1,2|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NOS1 / nNOS Antibody (aa1422-1433) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.|
|Cellular Location||Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity).|
|Tissue Location||Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Hall A.V.,et al.J. Biol. Chem. 269:33082-33090(1994).
Fujisawa H.,et al.J. Neurochem. 63:140-145(1994).
Nakane M.,et al.FEBS Lett. 316:175-180(1993).
Park C.-S.,et al.Cell. Mol. Neurobiol. 16:499-515(1996).
Wang Y.,et al.J. Biol. Chem. 272:11392-11401(1997).
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