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SP3 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - SP3 Antibody (C-Terminus) ALS11830
    Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed...
    detail
  • IHC - SP3 Antibody (C-Terminus) ALS11830
    Anti-SP3 antibody IHC of human tonsil.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q02447
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 82kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 6670
Other Names Transcription factor Sp3, SPR-2, SP3
Target/Specificity Peptide mapping to the carboxy terminus of human Sp3
Reconstitution & Storage +4°C, avoid freezing
PrecautionsSP3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SP3
Function Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
Cellular Location Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies
Tissue Location Ubiquitously expressed.
Volume 50 µl
Citations (0)
citation

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Background

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.

References

Hernandez E.M.,et al.J. Biochem. Mol. Biol. 35:273-282(2002).
Moran K.M.,et al.Gene 341:235-247(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Oleksiak M.F.,et al.Mol. Biol. Evol. 19:2026-2029(2002).
Meyer-Grahle U.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS11830
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