SP3 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q02447 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 82kDa |
Dilution | IHC-P (1:50) |
Gene ID | 6670 |
---|---|
Other Names | Transcription factor Sp3, SPR-2, SP3 |
Target/Specificity | Peptide mapping to the carboxy terminus of human Sp3 |
Reconstitution & Storage | +4°C, avoid freezing |
Precautions | SP3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SP3 |
---|---|
Function | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. |
Cellular Location | Nucleus. Nucleus, PML body. Note=Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies |
Tissue Location | Ubiquitously expressed. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone- induction and house-keeping.
References
Hernandez E.M.,et al.J. Biochem. Mol. Biol. 35:273-282(2002).
Moran K.M.,et al.Gene 341:235-247(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Oleksiak M.F.,et al.Mol. Biol. Evol. 19:2026-2029(2002).
Meyer-Grahle U.,et al.Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
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