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Tuberin / TSC2 Antibody (phospho-Ser664)

Rabbit Polyclonal Antibody

     
  • ICC - Tuberin / TSC2 Antibody (phospho-Ser664) ALS11834
    0
  • ICC - Tuberin / TSC2 Antibody (phospho-Ser664) ALS11834
    Untreated Hela cells (Panel A), or overnight nocodazole treated Hela cells (Panel B) stained...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, ICC
Primary Accession P49815
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 201kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 7249
Other Names Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Target/Specificity Modified peptide
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTuberin / TSC2 Antibody (phospho-Ser664) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSC2
Synonyms TSC4
Function In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta
Research Areas
Citations (0)

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Background

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

References

Nellist M.,et al.Cell 75:1305-1315(1993).
Sampson J.R.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Xu L.,et al.Genomics 27:475-480(1995).
Maheshwar M.M.,et al.Hum. Mol. Genet. 5:131-137(1996).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).

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$ 395.00
Cat# ALS11834
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