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FAIM2 / LIFEGUARD Antibody (aa1-50)

Rabbit Polyclonal Antibody

     
  • WB - FAIM2 / LIFEGUARD Antibody (aa1-50) ALS11915
    Western blot of human Lifeguard in human brain lysate in the 1)?absence and 2) presence of...
  • IHC - FAIM2 / LIFEGUARD Antibody (aa1-50) ALS11915
    Anti-FAIM2 antibody IHC of human brain, cerebellum.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9BWQ8
Reactivity Human, Mouse, Rat, Monkey, Chicken, Opossum, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 35kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 23017
Other Names Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2
Target/Specificity A portion of amino acids 1-50 of human Lifeguard
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFAIM2 / LIFEGUARD Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FAIM2
Synonyms KIAA0950, LFG, LFG2, NMP35, TMBIM2
Function Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
Cellular Location Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane
Tissue Location Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.
Research Areas
Citations (0)

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Background

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

References

Somia N.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11915
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