|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Chicken, Opossum, Dog|
|Dilution||IHC-P (10 µg/ml), WB (1-3 µg/ml),|
|Other Names||Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Target/Specificity||A portion of amino acids 1-50 of human Lifeguard|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||FAIM2 / LIFEGUARD Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA0950, LFG, LFG2, NMP35, TMBIM2|
|Function||Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.|
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Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
Somia N.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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