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FAIM2 / LIFEGUARD Antibody (aa1-50)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9BWQ8 |
| Reactivity | Human, Mouse, Rat, Monkey, Chicken, Opossum, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35kDa |
| Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 23017 |
|---|---|
| Other Names | Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Target/Specificity | A portion of amino acids 1-50 of human Lifeguard |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | FAIM2 / LIFEGUARD Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FAIM2 |
|---|---|
| Synonyms | KIAA0950, LFG, LFG2, NMP35, TMBIM2 |
| Function | Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Membrane raft Postsynaptic cell membrane |
| Tissue Location | Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.
References
Somia N.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).
Nagase T.,et al.DNA Res. 6:63-70(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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