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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   RNF174 / MARCH4 Antibody (aa300-350)   

RNF174 / MARCH4 Antibody (aa300-350)

Rabbit Polyclonal Antibody

     
  • IHC - RNF174 / MARCH4 Antibody (aa300-350) ALS11927
    Anti-MARCH4 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9P2E8
Reactivity Human, Mouse, Rat, Zebrafish, Chicken, Opossum, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 46kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 57574
Other Names E3 ubiquitin-protein ligase MARCH4, 6.3.2.-, Membrane-associated RING finger protein 4, Membrane-associated RING-CH protein IV, MARCH-IV, RING finger protein 174, MARCH4, KIAA1399, RNF174
Target/Specificity A portion of amino acids 300-350 of human RNF174
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsRNF174 / MARCH4 Antibody (aa300-350) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARCH4
Synonyms KIAA1399, RNF174
Function E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Expressed in brain and placenta.
Research Areas
Citations (0)

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Background

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

References

Nagase T.,et al.DNA Res. 7:65-73(2000).
Bartee E.,et al.J. Virol. 78:1109-1120(2004).

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$ 395.00
Cat# ALS11927
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