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FOXC1 Antibody (aa250-300)

Rabbit Polyclonal Antibody

     
  • WB - FOXC1 Antibody (aa250-300) ALS11931
    Western blot of human FOXC1 in humanuliver lysate in the 1) absence, 2) presence of immunizing...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q12948
Reactivity Human, Mouse, Rat, Monkey, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution IHC-P (1:200), WB (1:250-1:1000),
Additional Information
Gene ID 2296
Other Names Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3, FOXC1, FKHL7, FREAC3
Target/Specificity A portion of amino acids 250-300 of human FOXC1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFOXC1 Antibody (aa250-300) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FOXC1
Synonyms FKHL7, FREAC3
Function Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Cellular Location Nucleus.
Tissue Location Expressed in all tissues and cell lines examined.
Research Areas
Citations (0)

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Background

Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.

References

Nishimura D.Y.,et al.Nat. Genet. 19:140-147(1998).
Mears A.J.,et al.Am. J. Hum. Genet. 63:1316-1328(1998).
Komatireddy S.,et al.Mol. Vis. 9:43-48(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Hromas R.,et al.Blood 81:2854-2859(1993).

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$ 395.00
Cat# ALS11931
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