|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Bovine|
|Dilution||IHC-P (1:200), WB (1:250-1:1000),|
|Other Names||Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3, FOXC1, FKHL7, FREAC3|
|Target/Specificity||A portion of amino acids 250-300 of human FOXC1|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||FOXC1 Antibody (aa250-300) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.|
|Tissue Location||Expressed in all tissues and cell lines examined.|
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Provided below are standard protocols that you may find useful for product applications.
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'- GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Nishimura D.Y.,et al.Nat. Genet. 19:140-147(1998).
Mears A.J.,et al.Am. J. Hum. Genet. 63:1316-1328(1998).
Komatireddy S.,et al.Mol. Vis. 9:43-48(2003).
Mungall A.J.,et al.Nature 425:805-811(2003).
Hromas R.,et al.Blood 81:2854-2859(1993).
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