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AQP2 / Aquaporin 2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - AQP2 / Aquaporin 2 Antibody (N-Terminus) ALS11950
    Anti-AQP2 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P41181
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 29kDa
Dilution ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 359
Other Names Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct, AQP2
Target/Specificity synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsAQP2 / Aquaporin 2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP2
Function Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Cellular Location Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated
Tissue Location Expressed in renal collecting tubules.
Research Areas
Citations (0)

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Background

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

References

Deen P.M.T.,et al.Science 264:92-94(1994).
Uchida S.,et al.J. Biol. Chem. 269:23451-23455(1994).
van Lieburg A.F.,et al.Am. J. Hum. Genet. 55:648-652(1994).
Sasaki S.,et al.J. Clin. Invest. 93:1250-1256(1994).
Marr N.,et al.Hum. Mol. Genet. 11:779-789(2002).

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$ 395.00
Cat# ALS11950
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