|Application ||WB, IHC-P, E|
|Dilution||ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml)|
|Other Names||Aquaporin-2, AQP-2, ADH water channel, Aquaporin-CD, AQP-CD, Collecting duct water channel protein, WCH-CD, Water channel protein for renal collecting duct, AQP2|
|Target/Specificity||synthetic peptide corresponding to N-terminal residues of human AQP2(aquaporin 2)|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||AQP2 / Aquaporin 2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|
|Cellular Location||Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein Cytoplasmic vesicle membrane; Multi- pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated|
|Tissue Location||Expressed in renal collecting tubules.|
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Provided below are standard protocols that you may find useful for product applications.
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Deen P.M.T.,et al.Science 264:92-94(1994).
Uchida S.,et al.J. Biol. Chem. 269:23451-23455(1994).
van Lieburg A.F.,et al.Am. J. Hum. Genet. 55:648-652(1994).
Sasaki S.,et al.J. Clin. Invest. 93:1250-1256(1994).
Marr N.,et al.Hum. Mol. Genet. 11:779-789(2002).
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