|Application ||WB, IHC-P, E|
|Dilution||ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml)|
|Other Names||Solute carrier family 40 member 1, Ferroportin-1, Iron-regulated transporter 1, SLC40A1, FPN1, IREG1, SLC11A3|
|Target/Specificity||synthetic peptide corresponding to N-terminal residues of human MTP1 (Metal transporter protein 1)|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||SLC40A1 / Ferroportin-1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FPN1, IREG1, SLC11A3|
|Function||May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).|
|Cellular Location||Cell membrane; Multi-pass membrane protein Note=Localized to the basolateral membrane of polarized epithelial cells|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
Abboud S.,et al.J. Biol. Chem. 275:19906-19912(2000).
McKie A.T.,et al.Mol. Cell 5:299-309(2000).
Donovan A.,et al.Nature 403:776-781(2000).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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