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> home > Products > Primary Antibodies > Signal Transduction > SLC40A1 / Ferroportin-1 Antibody (N-Terminus)
SLC40A1 / Ferroportin-1 Antibody (N-Terminus)
Rabbit Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9NP59 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63kDa |
| Dilution | ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml) |
| Gene ID | 30061 |
|---|---|
| Other Names | Solute carrier family 40 member 1, Ferroportin-1, Iron-regulated transporter 1, SLC40A1, FPN1, IREG1, SLC11A3 |
| Target/Specificity | synthetic peptide corresponding to N-terminal residues of human MTP1 (Metal transporter protein 1) |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SLC40A1 / Ferroportin-1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC40A1 (HGNC:10909) |
|---|---|
| Function | Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of hepatocytoma WIF-B cells. |
| Tissue Location | Detected in erythrocytes (at protein level) (PubMed:23219802). Expressed in placenta, intestine, muscle and spleen (PubMed:10747949). Highly expressed in mature red blood (PubMed:29599243). |
Research Areas
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$ 467.50
Cat# ALS11961
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