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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD63 Antibody (clone MEM-259)   

CD63 Antibody (clone MEM-259)

Mouse Monoclonal Antibody

     
  • IHC - CD63 Antibody (clone MEM-259) ALS11982
    Anti-CD63 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, IP, Flo
Primary Accession P08962
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names MEM-259
Calculated MW 26kDa
Dilution ICC, IHC-P (10 µg/ml),
Additional Information
Gene ID 967
Other Names CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, LAMP-3, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, CD63, CD63, MLA1, TSPAN30
Target/Specificity HPB-ALL T cell line
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCD63 Antibody (clone MEM-259) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD63
Synonyms MLA1, TSPAN30
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Cellular Location Cell membrane; Multi- pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi- pass membrane protein. Endosome, multivesicular body. Melanosome. Secreted, exosome. Cell surface. Note=Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre- melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903)
Tissue Location Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages
Research Areas
Citations (0)

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Background

Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

References

Hotta H.,et al.Cancer Res. 48:2955-2962(1988).
Rapp G.,et al.DNA Cell Biol. 9:479-485(1990).
Metzelaar M.J.,et al.J. Biol. Chem. 266:3239-3245(1991).
Wang M.X.,et al.Arch. Ophthalmol. 110:399-404(1992).
Hotta H.,et al.Biochem. Biophys. Res. Commun. 185:436-442(1992).

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$ 395.00
Cat# ALS11982
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