|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (10 µg/ml), WB (1-3 µg/ml),|
|Other Names||Aldo-keto reductase family 1 member B10, 1.1.1.-, ARL-1, Aldose reductase-like, Aldose reductase-related protein, ARP, hARP, Small intestine reductase, SI reductase, AKR1B10, AKR1B11|
|Target/Specificity||A portion of amino acids 100-200 of human AKR1B10 protein was used as the immunogen.|
|Reconstitution & Storage||Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.|
|Precautions||AKR1B10 Antibody (aa100-200) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.|
|Cellular Location||Lysosome. Secreted. Note=Secreted through a lysosome-mediated non-classical pathway|
|Tissue Location||Found in many tissues. Highly expressed in small intestine, colon and adrenal gland|
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Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.
Cao D.,et al.J. Biol. Chem. 273:11429-11435(1998).
Hyndman D.J.,et al.Biochim. Biophys. Acta 1399:198-202(1998).
Heringlake S.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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