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FPR1 / FPR Antibody (aa176-190)

Rabbit Polyclonal Antibody

     
  • WB - FPR1 / FPR Antibody (aa176-190) ALS12071
    Western blot of FPR1 in the 1) absence and 2) presence of immunizing peptide in human liver...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P21462
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 38kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 2357
Other Names fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor, FPR1
Target/Specificity A portion of amino acids 150-200 of human FPR1 was used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsFPR1 / FPR Antibody (aa176-190) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FPR1
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456).
Cellular Location Cell membrane; Multi- pass membrane protein
Tissue Location Neutrophils.
Research Areas
Citations (0)

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Background

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456).

References

Boulay F.,et al.Biochem. Biophys. Res. Commun. 168:1103-1109(1990).
Boulay F.,et al.Biochemistry 29:11123-11133(1990).
Murphy P.M.,et al.J. Biol. Chem. 266:12560-12567(1991).
Bao L.,et al.Genomics 13:437-440(1992).
Perez H.D.,et al.Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12071
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