HTRA3 Antibody (aa250-300)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
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Primary Accession | P83110 |
Reactivity | Human, Rat, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 49kDa |
Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
Gene ID | 94031 |
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Other Names | Serine protease HTRA3, 3.4.21.-, High-temperature requirement factor A3, Pregnancy-related serine protease, HTRA3, PRSP |
Target/Specificity | A synthetic peptide within amino acid residues 250-300 of human HtrA3 was used as immunogen. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | HTRA3 Antibody (aa250-300) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | HTRA3 |
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Synonyms | PRSP |
Function | Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724). |
Cellular Location | Secreted. Note=Secretion increased during decidualization of endometrial stromal cells |
Tissue Location | Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney |
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Background
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization.
References
Nie G.-Y.,et al.Biochem. J. 371:39-48(2003).
Southan C.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Bowden M.A.,et al.Gynecol. Oncol. 103:253-260(2006).
Narkiewicz J.,et al.Oncol. Rep. 21:1529-1537(2009).
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