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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   OLFM4 / Olfactomedin 4 Antibody (aa400-450)   

OLFM4 / Olfactomedin 4 Antibody (aa400-450)

Rabbit Polyclonal Antibody

     
  • IHC - OLFM4 / Olfactomedin 4 Antibody (aa400-450) ALS12097
    Anti-OLFM4 antibody IHC of human colon.
  • WB - OLFM4 / Olfactomedin 4 Antibody (aa400-450) ALS12097
    Western blot of human Olfactomedin 4 in human liver lysate in the 1) absence and 2) presence of...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q6UX06
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 10562
Other Names Olfactomedin-4, OLM4, Antiapoptotic protein GW112, G-CSF-stimulated clone 1 protein, hGC-1, hOLfD, OLFM4, GW112
Target/Specificity A portion of amino acids 400-450 of human Olfactomedin 4
Reconstitution & Storage Long term: -20°C; Short term: -20°C
PrecautionsOLFM4 / Olfactomedin 4 Antibody (aa400-450) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OLFM4
Synonyms GW112
Function May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Cellular Location Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).
Tissue Location Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.
Research Areas
Citations (0)

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Background

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

References

Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Dunham A.,et al.Nature 428:522-528(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang J.,et al.Gene 283:83-93(2002).
Zhang X.,et al.Cancer Res. 64:2474-2481(2004).

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$ 395.00
Cat# ALS12097
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