|Application ||WB, IHC-P|
|Reactivity||Human, Rabbit, Monkey|
|Dilution||IHC-P (5 µg/ml), WB (1-3 µg/ml),|
|Other Names||Porimin, Keratinocytes-associated transmembrane protein 3, KCT-3, Pro-oncosis receptor inducing membrane injury, Transmembrane protein 123, TMEM123, KCT3|
|Target/Specificity||A synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAI of human Porimin; GenBank no. AAG2164.1. This sequence is 100% conserved in cow, and 93% conserved in rat, mouse, and chicken.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TMEM123 / Porimin Antibody (aa173-188) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.|
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Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
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Bonkobara M.,et al.Br. J. Dermatol. 148:654-664(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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