|Application ||WB, IHC-P|
|Reactivity||Human, Rabbit, Monkey|
|Dilution||IHC-P (5 µg/ml), WB (1-3 µg/ml),|
|Other Names||Porimin, Keratinocytes-associated transmembrane protein 3, KCT-3, Pro-oncosis receptor inducing membrane injury, Transmembrane protein 123, TMEM123, KCT3|
|Target/Specificity||A synthetic peptide corresponding to amino acids 173-188 SRRGIRYRTIDEHDAI of human Porimin; GenBank no. AAG2164.1. This sequence is 100% conserved in cow, and 93% conserved in rat, mouse, and chicken.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TMEM123 / Porimin Antibody (aa173-188) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
Ma F.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:9778-9783(2001).
Bonkobara M.,et al.Br. J. Dermatol. 148:654-664(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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