|Application ||WB, IHC-P|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Target/Specificity||A C-terminal peptide corresponding to amino acids 254-269 of human BLyS.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||BAFF Antibody (aa254-269) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Function||Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Shu H.-B.,et al.J. Leukoc. Biol. 65:680-683(1999).
Schneider P.,et al.J. Exp. Med. 189:1747-1756(1999).
Moore P.A.,et al.Science 285:260-263(1999).
Gavin A.L.,et al.J. Biol. Chem. 278:38220-38228(2003).
Lahiri A.,et al.J. Autoimmun. 39:189-198(2012).
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