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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   BAFF Antibody (aa254-269)   

BAFF Antibody (aa254-269)

Rabbit Polyclonal Antibody

     
  • WB - BAFF Antibody (aa254-269) ALS12122
    Western blot of BAFF/BLyS in mouse and human cell lysates.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y275
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 31kDa
Dilution IHC-P (10 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 10673
Other Names Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4
Target/Specificity A C-terminal peptide corresponding to amino acids 254-269 of human BLyS.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsBAFF Antibody (aa254-269) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFSF13B
Synonyms BAFF, BLYS, TALL1, TNFSF20, ZTNF4
Function Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines
Research Areas
Citations (0)

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Background

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

References

Shu H.-B.,et al.J. Leukoc. Biol. 65:680-683(1999).
Schneider P.,et al.J. Exp. Med. 189:1747-1756(1999).
Moore P.A.,et al.Science 285:260-263(1999).
Gavin A.L.,et al.J. Biol. Chem. 278:38220-38228(2003).
Lahiri A.,et al.J. Autoimmun. 39:189-198(2012).

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$ 395.00
Cat# ALS12122
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